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The antibody against CHAF1A was raised in rabbit using the Human CHAF1A as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
The antibody against CHAF1A was raised in rabbit using the Human CHAF1A as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
$600.00
| Cat.No | ADC-48952A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CHAF1A |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.02% sodium azide |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Human CHAF1A | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q13111 |
Uniprot Id
Q13111
Target Species
Human
Target Name
CHAF1A
Target Full Name
Chromatin assembly factor 1 subunit A
Target Function
Core component of the CAF-1 complex, a complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci.
Target Subcellular Location
Nucleus. Note=DNA replication foci.
Target Protein Families
CHAF1A family
Target Synonyms
CAF 1; CAF 1 subunit A; CAF; CAF I 150 kDa subunit; CAF I p150; CAF-1 subunit A; CAF-I 150 kDa subunit; CAF-I p150; CAF1; CAF1A_HUMAN; CAF1B; CAF1P150; CHAF1A; Chromatin assembly factor 1 subunit A; Chromatin Assembly Factor 1 Subunit A p150; Chromatin assembly factor I (150 kDa); Chromatin assembly factor I 150 kDa; Chromatin assembly factor I p150 subunit; DCAF1; hp150; MGC71229; P150
Target Background
Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).
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