Rabbit anti-Human CHMP6 Polyclonal Antibody

Uniprot Id

Q96FZ7

Target Species

Human

Target Name

CHMP6

Target Full Name

Charged multivesicular body protein 6

Target Function

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.

Target Subcellular Location

Endomembrane system. Endosome membrane; Lipid-anchor. Late endosome membrane. Membrane; Lipid-anchor. Note=Localizes to endosomal membranes.

Target Protein Families

SNF7 family

Target Tissue Specificity

Ubiquitously expressed.

Target Synonyms

Charged multivesicular body protein 6; chmp6; CHMP6_HUMAN; Chromatin modifying protein 6; Chromatin-modifying protein 6; FLJ11749; hVps 20; hVps20; novel SNF7 protein; OTTMUSP00000004363; RGD1565325; RP24 225K18.4; Vacuolar protein sorting associated protein 20; Vacuolar protein sorting-associated protein 20; Vps 20; Vps20

Target Background

This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein family. Proteins in this family are part of the ESCRT-III (endosomal sorting complex required for transport III) which degrades surface receptors, and in biosynthesis of endosomes.