Rabbit anti-Human CHTF18 Polyclonal Antibody

The antibody against CHTF18 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 794-975 of human CHTF18 (NP_071375.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

ADA-07072A

Number

Cat.No	ADA-07072A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	CHTF18
Target Synonyms	CHL12; Ctf18; RUVBL; C16orf41; C321D2.2; C321D2.3; C321D2.4; CHTF18	Form	Liquid
Species Reactivity	Human, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa	Application	ELISA, WB, IF/ICC

Cat.No

ADA-07072A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

CHTF18

Target Synonyms

CHL12; Ctf18; RUVBL; C16orf41; C321D2.2; C321D2.3; C321D2.4; CHTF18

Form

Liquid

Species Reactivity

Human, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa

Application

ELISA, WB, IF/ICC

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 794-975 of human CHTF18 (NP_071375.1).	Target Species	Human
Immunogen Sequence	GTMLAYSLTYRQERTPDGQYIYRLEPNVEELCRFPELPARKPLTYQTKQLIAREIEVEKMRRAEASARVENSPQVDGSPPGLEGLLGGIGEKGVHRPAPRNHEQRLEHIMRRAAREEQPEKDFFGRVVVRSTAVPSAGDTAPEQDSVERRMGTAVGRSEVWFRFNEGVSNAVRRSLYIRDLL	Uniprot ID	Q8WVB6

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 794-975 of human CHTF18 (NP_071375.1).

Target Species

Human

Immunogen Sequence

GTMLAYSLTYRQERTPDGQYIYRLEPNVEELCRFPELPARKPLTYQTKQLIAREIEVEKMRRAEASARVENSPQVDGSPPGLEGLLGGIGEKGVHRPAPRNHEQRLEHIMRRAAREEQPEKDFFGRVVVRSTAVPSAGDTAPEQDSVERRMGTAVGRSEVWFRFNEGVSNAVRRSLYIRDLL

Uniprot ID

Q8WVB6

Background Information

Uniprot Id

Q8WVB6
Target Species

Human
Target Name

CHTF18
Target Full Name

Chromosome transmission fidelity protein 18 homolog
Target Function

Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage.
Target Subcellular Location

Nucleus. Note=Associates with chromatin during S phase.
Target Protein Families

Activator 1 small subunits family, CTF18 subfamily
Target Synonyms

6030457M03Rik ; C16orf41; C321D2.2; C321D2.3; C321D2.4; CHL12; chromosome transmission fidelity factor 18 homolog (S. cerevisiae); Chromosome transmission fidelity protein 18 homolog; chtf18; Ctf18; CTF18_HUMAN; hCTF18; MGC38008; RUVBL
Target Background

This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with other proteins, including RFC complex 3, to form a clamp loader complex that plays a role in sister chromatid cohesion during metaphase-anaphase transition.

Rabbit anti-Human CHTF18 Polyclonal Antibody

Specifications

Immunogen Information

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