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The antibody against CIT was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Citron. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, ELISA.
The antibody against CIT was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Citron. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, ELISA.
$167.00
| Cat.No | ADC-36515A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CIT |
| Target Synonyms | CIT antibody; CRIK antibody; KIAA0949 antibody; STK21Citron Rho-interacting kinase antibody; CRIK antibody; EC 2.7.11.1 antibody; Serine/threonine-protein kinase 21 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human Citron. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O14578 |
Uniprot Id
O14578
Target Species
Human
Target Name
CIT
Target Full Name
Citron Rho-interacting kinase
Target Function
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.
Target Involvement
Microcephaly 17, primary, autosomal recessive (MCPH17)
Target Subcellular Location
Cytoplasm.
Target Protein Families
Protein kinase superfamily, AGC Ser/Thr protein kinase family
Target Synonyms
CIT; CRIK; KIAA0949; STK21Citron Rho-interacting kinase; CRIK; EC 2.7.11.1; Serine/threonine-protein kinase 21
Target Background
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants.
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