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The antibody against CLIC1 was raised in Rabbit using the recombinant Protein corresponding to a sequence within amino acids 42-241 of human CLIC1(NP_001279.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, IP, ELISA.
The antibody against CLIC1 was raised in Rabbit using the recombinant Protein corresponding to a sequence within amino acids 42-241 of human CLIC1(NP_001279.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, IP, ELISA.
| Cat.No | ADA-08125A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CLIC1 |
| Target Synonyms | G6; CL1C1; NCC27; CLCNL1; [KD Validated] CLIC1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, MCF7 | Application | ELISA, WB, IF/ICC, IP |
| Immunogen Description | Recombinant Protein corresponding to a sequence within amino acids 42-241 of human CLIC1(NP_001279.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | NVTTVDTKRRTETVQKLCPGGQLPFLLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAALNPESNTAGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVAKALK | Uniprot ID | O00299 |
Uniprot Id
O00299
Target Species
Human
Target Name
CLIC1
Target Full Name
Chloride intracellular channel protein 1
Target Function
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
Target Subcellular Location
Nucleus. Nucleus membrane; Single-pass membrane protein. Cytoplasm. Cell membrane; Single-pass membrane protein.
Target Protein Families
Chloride channel CLIC family
Target Tissue Specificity
Expression is prominent in heart, placenta, liver, kidney and pancreas.
Target Synonyms
CLIC1; G6; NCC27; Chloride intracellular channel protein 1; Chloride channel ABP; Nuclear chloride ion channel 27; Regulatory nuclear chloride ion channel protein; hRNCC
Target Background
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.
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