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Rabbit anti-Human CLIC3 Polyclonal Antibody

The antibody against CLIC3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 87-236 of human CLIC3 (NP_004660.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-05125A

The antibody against CLIC3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 87-236 of human CLIC3 (NP_004660.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

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Specifications


Cat.No ADA-05125A ClonalityPolyclonal
Host SpeciesRabbitTarget NameCLIC3
Target SynonymsCLIC3FormLiquid
Species ReactivityHuman, Mouse, RatIsotypeIgG
Storage Buffer50% Glycerol, PBS with 0.01% thimerosal, pH7.3.Purification MethodAffinity purification
Positive SamplesHeLa, Mouse lung, Rat lungApplicationELISA, WB

Immunogen Information


Immunogen DescriptionRecombinant fusion protein containing a sequence corresponding to amino acids 87-236 of human CLIC3 (NP_004660.2).Target SpeciesHuman
Immunogen SequenceGPPDFPSLAPRYRESNTAGNDVFHKFSAFIKNPVPAQDEALYQQLLRALARLDSYLRAPLEHELAGEPQLRESRRRFLDGDRLTLADCSLLPKLHIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYTCPHSAEILAAYRPAVHPRUniprot IDO95833
Background Information
  • Uniprot Id

    O95833

  • Target Species

    Human

  • Target Name

    CLIC3

  • Target Full Name

    Chloride intracellular channel protein 3

  • Target Function

    Can insert into membranes and form chloride ion channels. May participate in cellular growth control.

  • Target Subcellular Location

    Nucleus. Membrane; Single-pass membrane protein. Cytoplasm.

  • Target Protein Families

    Chloride channel CLIC family

  • Target Tissue Specificity

    Detected in placenta (at protein level). Widely expressed. High expression is found in placenta followed by lung and heart. Low expression in skeletal muscle, kidney and pancreas.

  • Target Synonyms

    CLIC3; Chloride intracellular channel protein 3

  • Target Background

    Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family.

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