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The antibody against CLK2 was raised in rabbit using the Synthesized peptide derived from internal of Human CLK2. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
The antibody against CLK2 was raised in rabbit using the Synthesized peptide derived from internal of Human CLK2. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
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Western blot analysis of extracts from COLO205 cells and A549 cells, using CLK2 antibody.
| Cat.No | ADC-42051A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CLK2 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human CLK2. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P49760 |
Uniprot Id
P49760
Target Species
Human
Target Name
CLK2
Target Full Name
Dual specificity protein kinase CLK2
Target Function
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN.
Target Subcellular Location
Nucleus.; [Isoform 1]: Nucleus. Nucleus speckle.; [Isoform 2]: Nucleus speckle.
Target Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, Lammer subfamily
Target Tissue Specificity
Endothelial cells. Expressed in androgen-dependent prostate cancer cells.
Target Research Area
Cell Biology
Target Synonyms
CDC like kinase 2; CDC-like kinase 2; CLK 2; CLK kinase; CLK2; Clk2 Scamp3; CLK2_HUMAN; Dual specificity protein kinase CLK2; hCLK 2; hCLK2; Tu52
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