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The antibody against CLTC was raised in rabbit using the Recombinant Human Clathrin heavy chain 1 protein (851-990aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against CLTC was raised in rabbit using the Recombinant Human Clathrin heavy chain 1 protein (851-990aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-55192A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CLTC |
| Target Synonyms | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17), CLH17 CLTCL2 KIAA0034, CLTC | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Clathrin heavy chain 1 protein (851-990aa) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q00610 |
Uniprot Id
Q00610
Target Species
Human
Target Name
CLTC
Target Full Name
Clathrin heavy chain 1
Target Function
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation.
Target Subcellular Location
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Melanosome. Cytoplasm, cytoskeleton, spindle.
Target Protein Families
Clathrin heavy chain family
Target Synonyms
Hc; CHC; CHC17; MRD56; CLH-17; CLTCL2; Clathrin heavy chain
Target Background
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.
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