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The antibody against CNTFR was raised in rabbit using the Fusion protein corresponding to a region derived from 23-342 amino acids of Human ciliary neurotrophic factor receptor as the immunogen. This antibody has been validated on ELISA, WB.
The antibody against CNTFR was raised in rabbit using the Fusion protein corresponding to a region derived from 23-342 amino acids of Human ciliary neurotrophic factor receptor as the immunogen. This antibody has been validated on ELISA, WB.
$297.00
Gel: 10%SDS-PAGE Lysate: 40 ug Mouse skeletal muscle tissue lysate Primary antibody: 1/300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 60 seconds
| Cat.No | ADC-43041A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CNTFR |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Storage Buffer | 0.05% sodium azide and 50% glycerol., pH 7.3, Supplied at 0.5mg/mL in phosphate buffered saline (without Mg2+ and Ca2+) | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Fusion protein corresponding to a region derived from 23-342 amino acids of Human ciliary neurotrophic factor receptor | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P26992 |
Uniprot Id
P26992
Target Species
Human
Target Name
CNTFR
Target Full Name
Ciliary neurotrophic factor receptor subunit alpha
Target Function
Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and IL27RA/WSX1.
Target Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor.
Target Protein Families
Type I cytokine receptor family, Type 3 subfamily
Target Tissue Specificity
Nervous system and skeletal muscle.
Target Synonyms
Ciliary neurotrophic factor receptor alpha; Ciliary neurotrophic factor receptor; Ciliary neurotrophic factor receptor subunit alpha; CNTF Receptor alpha; CNTF receptor subunit alpha; CNTFR Alpha; CNTFR; CNTFR-alpha; CNTFR_HUMAN
Target Background
This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene.
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