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The antibody against Coilin was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 297-576 of human Coilin (NP_004636.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IP, ELISA.
The antibody against Coilin was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 297-576 of human Coilin (NP_004636.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IP, ELISA.
| Cat.No | ADA-11104A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Coilin |
| Target Synonyms | CLN80; p80-coilin; Coilin | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, HepG2, MCF7, Rat testis | Application | ELISA, WB, IP |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 297-576 of human Coilin (NP_004636.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P38432 | Immunogen Sequence |
Uniprot Id
P38432
Target Species
Human
Target Name
COIL
Target Full Name
Coilin
Target Function
Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.
Target Subcellular Location
Nucleus. Nucleus, Cajal body.
Target Protein Families
Coilin family
Target Tissue Specificity
Found in all the cell types examined.
Target Synonyms
CLN 80; CLN80; COIL; COIL_HUMAN; Coilin; Coilin p80; p80; P80 coilin
Target Background
The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14.
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