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Rabbit anti-Human COL3A1 Polyclonal Antibody

The antibody against COL3A1 was raised in rabbit using the Recombinant Human Collagen alpha-1(III) chain protein (1222-1465AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.

ADC-50331A

The antibody against COL3A1 was raised in rabbit using the Recombinant Human Collagen alpha-1(III) chain protein (1222-1465AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.

$299.00

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Specifications


Cat.No ADC-50331A ClonalityPolyclonal
Host SpeciesRabbitTarget NameCOL3A1
FormLiquidSpecies ReactivityHuman
IsotypeIgGStorage Buffer0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4
Purification Method>95%, Protein G purifiedConjugateNon-conjugated
ApplicationELISAStorageUpon receipt

Immunogen Information


Immunogen DescriptionRecombinant Human Collagen alpha-1(III) chain protein (1222-1465AA)Target SpeciesHuman
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDP02461
Background Information
  • Uniprot Id

    P02461

  • Target Species

    Human

  • Target Name

    COL3A1

  • Target Full Name

    Collagen alpha-1(III) chain

  • Target Function

    Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.

  • Target Involvement

    Ehlers-Danlos syndrome 3 (EDS3); Ehlers-Danlos syndrome 4 (EDS4)

  • Target Subcellular Location

    Secreted, extracellular space, extracellular matrix.

  • Target Protein Families

    Fibrillar collagen family

  • Target Synonyms

    EDS4A; EDSVASC; PMGEDSV; Collagen III alpha 1/COL3A1

  • Target Background

    This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome type IV, and with aortic and arterial aneurysms.

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