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The antibody against COL4A5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1462-1691 of human COL4A5 (NP_203699.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against COL4A5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1462-1691 of human COL4A5 (NP_203699.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-00925A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | COL4A5 |
| Target Synonyms | ATS; ASLN; ATS1; CA54; COL4A5 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 22Rv1, HepG2, NCI-H460 | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1462-1691 of human COL4A5 (NP_203699.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P29400 | Immunogen Sequence |
Uniprot Id
P29400
Target Species
Human
Target Name
COL4A5
Target Full Name
Collagen alpha-5(IV) chain
Target Function
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Target Involvement
Alport syndrome, X-linked (APSX)
Target Subcellular Location
Secreted, extracellular space, extracellular matrix, basement membrane.
Target Protein Families
Type IV collagen family
Target Tissue Specificity
Isoform 2 is found in kidney.
Target Synonyms
CO4A5_HUMAN; COL4A5; Collagen alpha-5(IV) chain
Target Background
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Alternatively spliced transcript variants have been identified for this gene.
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