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The antibody against COL4A5 was raised in rabbit using the Recombinant Human Collagen alpha-5(IV) chain protein (1184-1235AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against COL4A5 was raised in rabbit using the Recombinant Human Collagen alpha-5(IV) chain protein (1184-1235AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
| Cat.No | ADC-02871A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | COL4A5 |
| Target Synonyms | CO4A5_HUMAN antibody; COL4A5 antibody; Collagen alpha-5(IV) chain antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Collagen alpha-5(IV) chain protein (1184-1235AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P29400 |
Uniprot Id
P29400
Target Species
Human
Target Name
COL4A5
Target Full Name
Collagen alpha-5(IV) chain
Target Function
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Target Involvement
Alport syndrome, X-linked (APSX)
Target Subcellular Location
Secreted, extracellular space, extracellular matrix, basement membrane.
Target Protein Families
Type IV collagen family
Target Tissue Specificity
Isoform 2 is found in kidney.
Target Synonyms
CO4A5_HUMAN; COL4A5; Collagen alpha-5(IV) chain
Target Background
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Alternatively spliced transcript variants have been identified for this gene.
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