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The antibody against COLEC12 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 60-270 of human COLEC12 (NP_569057.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against COLEC12 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 60-270 of human COLEC12 (NP_569057.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-09065A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | COLEC12 |
| Target Synonyms | CLP1; NSR2; SRCL; SCARA4; COLEC12 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, A-549, Mouse liver, Mouse lung, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 60-270 of human COLEC12 (NP_569057.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q5KU26 | Immunogen Sequence |
Uniprot Id
Q5KU26
Target Species
Human
Target Name
COLEC12
Target Full Name
Collectin-12
Target Function
Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease.
Target Subcellular Location
Membrane; Single-pass type II membrane protein. Note=Forms clusters on the cell surface.
Target Tissue Specificity
Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed
Target Synonyms
CL P1; CL-P1; CLP1; COL12_HUMAN; COLEC 12; colec12; Collectin placenta 1; Collectin placenta protein 1; Collectin sub family member 12; Collectin-12; hCL P1; hCL-P1; NSR2; Nurse cell scavenger receptor 2; SCARA4; Scavenger receptor class A member 4; Scavenger receptor with C type lectin; Scavenger receptor with C-type lectin; SRCL
Target Background
This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells.
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