Rabbit anti-Human Complement C4A Monoclonal Antibody

Uniprot Id

P0C0L4

Target Species

Human

Target Name

C4A

Target Full Name

Complement C4-A

Target Function

Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.; Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Target Involvement

Complement component 4A deficiency (C4AD); Systemic lupus erythematosus (SLE)

Target Subcellular Location

Secreted. Cell junction, synapse. Cell projection, axon. Cell projection, dendrite.

Target Tissue Specificity

Complement component C4 is expressed at highest levels in the liver, at moderate levels in the adrenal cortex, adrenal medulla, thyroid gland, and the kidney, and at lowest levels in the heart, ovary, small intestine, thymus, pancreas and spleen. The extr

Target Synonyms

Acidic C4; Acidic complement C4; Basic C4; Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; C4; Chido form; C4; Rodgers from; C4A anaphylatoxin; C4A; C4A2; C4A3; C4A4; C4A6; C4AD; C4B; C4B_2; C4B1; C4B12; C4B2; C4B3; C4BD; C4F; C4S; CH; Chido form of C4; CO4; CO4A_HUMAN; Complement C4 A; Complement C4 B; Complement C4 gamma chain; complement C4-A; complement C4-B; complement C4-B-like; complement C4B1a; Complement component 4A (Rodgers blood group); Complement component 4A; complement component 4B (Chido blood group); complement component 4B (Chido blood group); copy 2; Complement component 4B (Childo blood group); Complement component 4B; Complement component 4F; Complement component 4S; CPAMD2; CPAMD3; RG; Rodgers form of C4

Target Background

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene.