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The antibody against COPS3 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human CSN3. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, IF, ELISA.
The antibody against COPS3 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human CSN3. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, IF, ELISA.
$167.00
Western Blot analysis of 3T3 cells using CSN3 Polyclonal Antibody
Western Blot analysis of NIH-3T3 Jurkat RAT-intestine cells using CSN3 Polyclonal Antibody2
| Cat.No | ADC-38946A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | COPS3 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human CSN3. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UNS2 |
Uniprot Id
Q9UNS2
Target Species
Human
Target Name
COPS3
Target Full Name
COP9 signalosome complex subunit 3
Target Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
CSN3 family
Target Tissue Specificity
Widely expressed. Expressed at high level in heart and skeletal muscle.
Target Synonyms
Constitutive photomorphogenic homolog subunit 3; COP 9 (constitutive photomorphogenic) subunit 3; COP 9 complex homolog subunit 3; COP 9 complex S3; COP 9 complex subunit 3; COP 9 constitutive photomorphogenic homolog subunit 3; COP 9 homolog; COP 9 signalosome complex subunit 3; COP 9 signalosome subunit 3; COP 9 subunit 3; COP9 (constitutive photomorphogenic) subunit 3; COP9 complex homolog subunit 3; COP9 complex S3; COP9 complex subunit 3; COP9 constitutive photomorphogenic homolog subunit 3; COP9 homolog; COP9 signalosome complex subunit 3; COP9 signalosome subunit 3; COP9 subunit 3; COPS 3; cops3; CSN 3; CSN3; CSN3_HUMAN; JAB 1 containing signalosome subunit 3; JAB1 containing signalosome subunit 3; JAB1-containing signalosome subunit 3; SGN 3; SGN3; Signalosome subunit 3
Target Background
The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene.
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