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The antibody against COQ7 was raised in rabbit using the Recombinant Human 5-demethoxyubiquinone hydroxylase, mitochondrial protein (37-217AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against COQ7 was raised in rabbit using the Recombinant Human 5-demethoxyubiquinone hydroxylase, mitochondrial protein (37-217AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human breast cancer using COQ7 Antibody at dilution of 1:1002
| Cat.No | ADC-40542A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | COQ7 |
| Form | Liquid | Species Reactivity | Human, Rat |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human 5-demethoxyubiquinone hydroxylase, mitochondrial protein (37-217AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q99807 |
Uniprot Id
Q99807
Target Species
Human
Target Name
COQ7
Target Full Name
5-demethoxyubiquinone hydroxylase, mitochondrial
Target Function
Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
Target Involvement
Coenzyme Q10 deficiency, primary, 8 (COQ10D8)
Target Subcellular Location
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Target Protein Families
COQ7 family
Target Tissue Specificity
Expressed dominantly in heart and skeletal muscle.
Target Synonyms
COQ7; 5-demethoxyubiquinone hydroxylase; mitochondrial; DMQ hydroxylase; EC 1.14.13.-; Timing protein clk-1 homolog; Ubiquinone biosynthesis monooxygenase COQ7
Target Background
The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene.
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