Rabbit anti-Human COTL1 Polyclonal Antibody

The antibody against COTL1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human COTL1 (NP_066972.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-09741A

Number

Cat.No	ADA-09741A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	COTL1
Target Synonyms	CLP; COTL1	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, Mouse kidney, 293T, Jurkat, Mouse lung, Mouse spleen, U-251MG	Application	ELISA, WB, IHC-P

Cat.No

ADA-09741A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

COTL1

Target Synonyms

CLP; COTL1

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, Mouse kidney, 293T, Jurkat, Mouse lung, Mouse spleen, U-251MG

Application

ELISA, WB, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human COTL1 (NP_066972.1).	Target Species	Human
Immunogen Sequence	MATKIDKEACRAAYNLVRDDGSAVIWVTFKYDGSTIVPGEQGAEYQHFIQQCTDDVRLFAFVRFTTGDAMSKRSKFALITWIGENVSGLQRAKTGTDKTLVKEVVQNFAKEFVISDRKELEEDFIKSELKKAGGANYDAQTE	Uniprot ID	Q14019

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human COTL1 (NP_066972.1).

Target Species

Human

Immunogen Sequence

MATKIDKEACRAAYNLVRDDGSAVIWVTFKYDGSTIVPGEQGAEYQHFIQQCTDDVRLFAFVRFTTGDAMSKRSKFALITWIGENVSGLQRAKTGTDKTLVKEVVQNFAKEFVISDRKELEEDFIKSELKKAGGANYDAQTE

Uniprot ID

Q14019

Background Information

Uniprot Id

Q14019
Target Species

Human
Target Name

COTL1
Target Full Name

Coactosin-like protein
Target Function

Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.
Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.
Target Protein Families

Actin-binding proteins ADF family, Coactosin subfamily
Target Tissue Specificity

Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas.
Target Research Area

Signal Transduction
Target Synonyms

CLP; Coactosin like 1; Coactosin-like protein; COTL1; COTL1_HUMAN; FLJ43657; MGC19733
Target Background

This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.

Rabbit anti-Human COTL1 Polyclonal Antibody

Specifications

Immunogen Information

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