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The antibody against CP was raised in rabbit using the Recombinant Human Ceruloplasmin protein (807-1050AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against CP was raised in rabbit using the Recombinant Human Ceruloplasmin protein (807-1050AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-46416A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CP |
| Target Synonyms | CERU_HUMAN antibody; Ceruloplasmin antibody; CP 2 antibody; CP antibody; CP2 antibody; Ferroxidase antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Ceruloplasmin protein (807-1050AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P00450 |
Uniprot Id
P00450
Target Species
Human
Target Name
CP
Target Full Name
Ceruloplasmin
Target Function
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense.
Target Involvement
Aceruloplasminemia (ACERULOP)
Target Subcellular Location
Secreted.
Target Protein Families
Multicopper oxidase family
Target Tissue Specificity
Expressed by the liver and secreted in plasma.
Target Research Area
Signal Transduction
Target Synonyms
CERU_HUMAN; Ceruloplasmin; CP 2; CP; CP2; Ferroxidase
Target Background
The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
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