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The antibody against CPN1 was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human CPN cat. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against CPN1 was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human CPN cat. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
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Western Blot analysis of Hela cells using CPN cat Polyclonal Antibody
Western Blot analysis of HELA cells using CPN cat Polyclonal Antibody2
| Cat.No | ADC-38963A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CPN1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the C-terminal region of Human CPN cat. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P15169 |
Uniprot Id
P15169
Target Species
Human
Target Name
CPN1
Target Full Name
Carboxypeptidase N catalytic chain
Target Function
Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
Target Involvement
Carboxypeptidase N deficiency (CPND)
Target Subcellular Location
Secreted, extracellular space.
Target Protein Families
Peptidase M14 family
Target Tissue Specificity
Synthesized in the liver and secreted in plasma.
Target Research Area
Signal Transduction
Target Synonyms
ACBP; Anaphylatoxin inactivator; Arginine carboxypeptidase; Carboxypeptidase N catalytic chain; Carboxypeptidase N polypeptide 1 50 kD; Carboxypeptidase N polypeptide 1; Carboxypeptidase N small subunit; Carboxypeptidase N subunit 1; CBPN_HUMAN; CPN; CPN1; Kininase 1; Kininase-1; Kininase1; Lysine carboxypeptidase; Plasma carboxypeptidase B; SCPN; Serum carboxypeptidase N
Target Background
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency.
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