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Rabbit anti-Human CRCP Polyclonal Antibody

The antibody against CRCP was raised in rabbit using the Recombinant Human DNA-directed RNA polymerase III subunit RPC9 protein (1-115AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.

ADC-09931A

The antibody against CRCP was raised in rabbit using the Recombinant Human DNA-directed RNA polymerase III subunit RPC9 protein (1-115AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.

$299.00

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Specifications


Cat.No ADC-09931A ClonalityPolyclonal
Host SpeciesRabbitTarget NameCRCP
FormLiquidSpecies ReactivityHuman
IsotypeIgGStorage Buffer0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4
Purification Method>95%, Protein G purifiedConjugateNon-conjugated
ApplicationELISA, IF, IHCStorageUpon receipt

Immunogen Information


Immunogen DescriptionRecombinant Human DNA-directed RNA polymerase III subunit RPC9 protein (1-115AA)Target SpeciesHuman
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDO75575
Background Information
  • Uniprot Id

    O75575

  • Target Species

    Human

  • Target Name

    CRCP

  • Target Full Name

    DNA-directed RNA polymerase III subunit RPC9

  • Target Function

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway.; Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.

  • Target Subcellular Location

    Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

  • Target Protein Families

    Eukaryotic RPC9 RNA polymerase subunit family

  • Target Tissue Specificity

    Ubiquitous. Most prevalent in testis.

  • Target Synonyms

    Calcitonin gene related peptide receptor component; Calcitonin gene related peptide receptor component protein; Calcitonin gene-related peptide-receptor component protein; CGRP receptor component protein; CGRP-RCP; CGRP-receptor component protein; CGRPRCP; CRCP; DNA-directed RNA polymerase III subunit RPC9; HsC17; RCP; RCP9 ; RNA polymerase III subunit C9; RPC9_HUMAN

  • Target Background

    This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

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