Rabbit anti-Human CREM Polyclonal Antibody

The antibody against CREM was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human CREM (NP_853549.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

ADA-09668A

Number

Cat.No	ADA-09668A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	CREM
Target Synonyms	ICER; CREM-2; hCREM-2; CREM	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, 293T, Mouse testis, RAW264.7	Application	ELISA, WB, IF/ICC

Cat.No

ADA-09668A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

CREM

Target Synonyms

ICER; CREM-2; hCREM-2; CREM

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, 293T, Mouse testis, RAW264.7

Application

ELISA, WB, IF/ICC

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CREM (NP_853549.1).	Target Species	Human
Immunogen Sequence	MSKCARKKYIKTNPRQMTMETVESQHDGSITASLTESKSAHVQTQTGQNSIPALAQVAAIAETDESAESEGVIDSHKRREILSRRPSYRKILNELSSDVP	Uniprot ID	Q03060

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CREM (NP_853549.1).

Target Species

Human

Immunogen Sequence

MSKCARKKYIKTNPRQMTMETVESQHDGSITASLTESKSAHVQTQTGQNSIPALAQVAAIAETDESAESEGVIDSHKRREILSRRPSYRKILNELSSDVP

Uniprot ID

Q03060

Background Information

Uniprot Id

Q03060
Target Species

Human
Target Name

CREM
Target Full Name

cAMP-responsive element modulator
Target Function

Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation.; May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.
Target Subcellular Location

Nucleus.; [Isoform 6]: Cytoplasm. Nucleus.
Target Protein Families

BZIP family
Target Tissue Specificity

Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
Target Synonyms

ICER; CREM-2; hCREM-2; CREM
Target Background

This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.

Rabbit anti-Human CREM Polyclonal Antibody

Specifications

Immunogen Information

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