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The antibody against CRH was raised in rabbit using the Synthetic peptide of Human CRH as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against CRH was raised in rabbit using the Synthetic peptide of Human CRH as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$299.00
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CRH Antibody(CRH Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CRH Antibody(CRH Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200)2
| Cat.No | ADC-28648A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CRH |
| Target Synonyms | CRHCorticoliberin antibody; Corticotropin-releasing factor antibody; CRF antibody; Corticotropin-releasing hormone antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthetic peptide of Human CRH | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P06850 |
Uniprot Id
P06850
Target Species
Human
Target Name
CRH
Target Full Name
Corticoliberin
Target Function
Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile.
Target Subcellular Location
Secreted.
Target Protein Families
Sauvagine/corticotropin-releasing factor/urotensin I family
Target Tissue Specificity
Produced by the hypothalamus and placenta.
Target Synonyms
CRHCorticoliberin; Corticotropin-releasing factor; CRF; Corticotropin-releasing hormone
Target Background
This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.
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