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The antibody against CRKL was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human CRKL (NP_005198.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against CRKL was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human CRKL (NP_005198.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00066A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CRKL |
| Target Synonyms | CRKL | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat heart, Jurkat, LO2, Mouse brain, SKOV3 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human CRKL (NP_005198.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P46109 | Immunogen Sequence |
Uniprot Id
P46109
Target Species
Human
Target Name
CRKL
Target Full Name
Crk-like protein
Target Function
May mediate the transduction of intracellular signals.
Target Protein Families
CRK family
Target Synonyms
Crk L; Crk like protein; Crk-like protein; Crkl; CRKL_HUMAN; Crkol; HGNC:2363 ; Oncogene CrkL; V crk avian sarcoma virus CT10 oncogene homolog like; v crk sarcoma virus CT10 oncogene homolog (avian) like; V crk sarcoma virus CT10 oncogene homolog avian like
Target Background
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
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