Rabbit anti-Human CTSK Polyclonal Antibody

Uniprot Id

P43235

Target Species

Human

Target Name

CTSK

Target Full Name

Cathepsin K

Target Function

Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.

Target Involvement

Pycnodysostosis (PKND)

Target Subcellular Location

Lysosome. Secreted. Apical cell membrane; Peripheral membrane protein; Extracellular side.

Target Protein Families

Peptidase C1 family

Target Tissue Specificity

Predominantly expressed in osteoclasts (bones). Expressed in thyroid epithelial cells.

Target Research Area

Signal Transduction

Target Synonyms

Cathepsin K; Cathepsin O; Cathepsin O1; Cathepsin O2; Cathepsin X; CATK_HUMAN; CTS02; Ctsk; CTSO; CTSO1; CTSO2; MGC23107; PKND; PYCD

Target Background

The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.