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The antibody against CUX1 was raised in rabbit using the Synthesized peptide derived from N-terminal of Human CUTL1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
The antibody against CUX1 was raised in rabbit using the Synthesized peptide derived from N-terminal of Human CUTL1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
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Western blot analysis of extracts from K562 cells, using CUTL1 antibody.
| Cat.No | ADC-42070A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CUX1 |
| Target Synonyms | CUX1 antibody; CUTL1Homeobox protein cut-like 1 antibody; CCAAT displacement protein antibody; CDP antibody; Homeobox protein cux-1 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from N-terminal of Human CUTL1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P39880 |
Uniprot Id
P39880
Target Species
Human
Target Name
CUX1
Target Full Name
Homeobox protein cut-like 1
Target Function
Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator.; Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1.
Target Subcellular Location
Nucleus.
Target Protein Families
CUT homeobox family
Target Synonyms
CUX1; CUTL1Homeobox protein cut-like 1; CCAAT displacement protein; CDP; Homeobox protein cux-1
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