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The antibody against CWC22 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 639-908 of human CWC22 (NP_065994.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against CWC22 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 639-908 of human CWC22 (NP_065994.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03442A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CWC22 |
| Target Synonyms | NCM; fSAPb; EIF4GL; CWC22 | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse liver, Mouse testis | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 639-908 of human CWC22 (NP_065994.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9HCG8 | Immunogen Sequence |
Uniprot Id
Q9HCG8
Target Species
Human
Target Name
CWC22
Target Full Name
Pre-mRNA-splicing factor CWC22 homolog
Target Function
Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay.
Target Subcellular Location
Nucleus. Nucleus speckle.
Target Protein Families
CWC22 family
Target Synonyms
CWC22; CWC22 spliceosome associated protein homolog (S. cerevisiae); CWC22 spliceosome associated protein homolog; CWC22_HUMAN; EIF4GL; fSAPb; Functional spliceosome associated protein b; KIAA1604; NCM; Nucampholin homolog; Pre-mRNA-splicing factor CWC22 homolog
Target Background
Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in cytosol and nuclear speck. Part of U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome.
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