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The antibody against CXCR1 was raised in rabbit using the Synthetic peptide from Human protein at AA range: 1-50 as the immunogen. This antibody exists as a non-conjugated antibody. The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. This antibody has been validated on IHC, ELISA.
The antibody against CXCR1 was raised in rabbit using the Synthetic peptide from Human protein at AA range: 1-50 as the immunogen. This antibody exists as a non-conjugated antibody. The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. This antibody has been validated on IHC, ELISA.
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Immunohistochemical analysis of paraffin-embedded Human-liver-cancer, antibody was diluted at 1:100
Immunohistochemical analysis of paraffin-embedded Human-liver-cancer, antibody was diluted at 1:1002
Immunohistochemical analysis of paraffin-embedded Human-placenta, antibody was diluted at 1:1003
| Cat.No | ADC-12951A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CXCR1 |
| Target Synonyms | CXCR1; CMKAR1; IL8RA; C-X-C chemokine receptor type 1; CXC-R1; CXCR-1; CDw128a; High affinity interleukin-8 receptor A; IL-8R A; IL-8 receptor type 1; CD antigen CD181 | Form | Liquid |
| Species Reactivity | Human | Storage Buffer | PH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol., PBS |
| Purification Method | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Synthetic peptide from Human protein at AA range: 1-50 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P25024 |
Uniprot Id
P25024
Target Species
Human
Target Name
CXCR1
Target Full Name
C-X-C chemokine receptor type 1
Target Function
Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
G-protein coupled receptor 1 family
Target Synonyms
CXCR1; CMKAR1; IL8RA; C-X-C chemokine receptor type 1; CXC-R1; CXCR-1; CDw128a; High affinity interleukin-8 receptor A; IL-8R A; IL-8 receptor type 1; CD antigen CD181
Target Background
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.
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