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The antibody against CXCR5/CD185 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-47 of human CXCR5 (NP_001707.1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against CXCR5/CD185 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-47 of human CXCR5 (NP_001707.1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
Western blot analysis of various lysates, using CXCR5/CD185 Rabbit mAb at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Negative control (NC): HeLa
Exposure time: 5s.
| Cat.No | ADA-15434A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CXCR5/CD185 |
| Target Synonyms | BLR1; CD185; MDR15; CXCR5/CD185 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Daudi, Raji | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-47 of human CXCR5 (NP_001707.1) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MNYPLTLEMDLENLEDLFWELDRLDNYNDTSLVENHLCPATEGPLMA | Uniprot ID | P32302 |
Uniprot Id
P32302
Target Species
Human
Target Name
CXCR5
Target Full Name
C-X-C chemokine receptor type 5
Target Function
Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
G-protein coupled receptor 1 family
Target Tissue Specificity
Expression in mature B-cells and Burkitt lymphoma cells.
Target Research Area
Cancer
Target Synonyms
CXCR5; BLR1; MDR15; C-X-C chemokine receptor type 5; CXC-R5; CXCR-5; Burkitt lymphoma receptor 1; Monocyte-derived receptor 15; MDR-15; CD antigen CD185
Target Background
This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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