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The antibody against CXCR6 was raised in rabbit using the Synthesized peptide derived from the N-terminal region of Human Bonzo. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against CXCR6 was raised in rabbit using the Synthesized peptide derived from the N-terminal region of Human Bonzo. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
$167.00
Western Blot analysis of HeLa cells using Bonzo Polyclonal Antibody.
| Cat.No | ADC-36964A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CXCR6 |
| Target Synonyms | CXCR6; BONZO; STRL33; TYMSTR; C-X-C chemokine receptor type 6; CXC-R6; CXCR-6; CDw186; G-protein coupled receptor STRL33; G-protein coupled receptor bonzo; CD antigen CD186 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the N-terminal region of Human Bonzo. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O00574 |
Uniprot Id
O00574
Target Species
Human
Target Name
CXCR6
Target Full Name
C-X-C chemokine receptor type 6
Target Function
Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
G-protein coupled receptor 1 family
Target Tissue Specificity
Expressed in lymphoid tissues and activated T cells.
Target Synonyms
CXCR6; BONZO; STRL33; TYMSTR; C-X-C chemokine receptor type 6; CXC-R6; CXCR-6; CDw186; G-protein coupled receptor STRL33; G-protein coupled receptor bonzo; CD antigen CD186
Target Background
The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the chemokine receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4.
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