Rabbit anti-Human CYP39A1 Polyclonal Antibody

Uniprot Id

Q9NYL5

Target Species

Human

Target Name

CYP39A1

Target Full Name

24-hydroxycholesterol 7-alpha-hydroxylase

Target Function

A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis. Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).

Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.

Target Protein Families

Cytochrome P450 family

Target Tissue Specificity

Liver specific.

Target Synonyms

24 hydroxycholesterol 7 alpha hydroxylase; 24-hydroxycholesterol 7-alpha-hydroxylase; CP39A_HUMAN; Cyp39a1; cytochrome P450 family 39; subfamily A polypeptide 1; Cytochrome P450 39A1; cytochrome P450 subfamily XXXIX (oxysterol 7 alpha hydroxylase) polypeptide 1; Cytochrome P450; family 39; subfamily a; polypeptide 1; hCYP39A1; Oxysterol 7 alpha hydroxylase ; Oxysterol 7-alpha-hydroxylase; oxysterol 7alpha hydroxylase

Target Background

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol. Alternate splicing results in multiple transcript variants.