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The antibody against CYP3A7 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human CYP3A7. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against CYP3A7 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human CYP3A7. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
$167.00
Western Blot analysis of 293T cells using CYP3A7 Polyclonal Antibody
| Cat.No | ADC-36196A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CYP3A7 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human CYP3A7. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P24462 |
Uniprot Id
P24462
Target Species
Human
Target Name
CYP3A7
Target Full Name
Cytochrome P450 3A7
Target Function
A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position. Mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal development. Also involved in the oxidative metabolism of xenobiotics including anticonvulsants.
Target Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Target Protein Families
Cytochrome P450 family
Target Tissue Specificity
Expressed in fetal liver (at protein level).
Target Research Area
Cardiovascular
Target Synonyms
Aryl hydrocarbon hydroxylase; CP37; CP3A7_HUMAN; CYP3A7; CYPIIIA7; Cytochrome P450 3A7; Cytochrome P450; family 3; subfamily A; polypeptide 7; Cytochrome P450; subfamily IIIA; polypeptide 7; Cytochrome P450-HFLA; Flavoprotein linked monooxygenase; Flavoprotein-linked monooxygenase; Microsomal monooxygenase; P 450(HFL33); P 450111A7; P450 HFLA; Xenobiotic monooxygenase
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