Rabbit anti-Human CYP4V2 Polyclonal Antibody

The antibody against CYP4V2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 200-300 of human CYP4V2 (NP_997235.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

ADA-02947A

Number

Cat.No	ADA-02947A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	CYP4V2
Target Synonyms	BCD; CYP4AH1; CYP4V2	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Positive Samples	Jurkat, Mouse liver, Rat liver, U-87MG	Application	ELISA, WB, IF/ICC

Cat.No

ADA-02947A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

CYP4V2

Target Synonyms

BCD; CYP4AH1; CYP4V2

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

Jurkat, Mouse liver, Rat liver, U-87MG

Application

ELISA, WB, IF/ICC

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 200-300 of human CYP4V2 (NP_997235.3).	Target Species	Human
Immunogen Sequence	GKNIGAQSNDDSE	Uniprot ID	Q6ZWL3

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 200-300 of human CYP4V2 (NP_997235.3).

Target Species

Human

Immunogen Sequence

GKNIGAQSNDDSE

Uniprot ID

Q6ZWL3

Background Information

Uniprot Id

Q6ZWL3
Target Species

Human
Target Name

CYP4V2
Target Full Name

Cytochrome P450 4V2
Target Function

A cytochrome P450 monooxygenase involved in fatty acid metabolism in the eye. Catalyzes the omega-hydroxylation of polyunsaturated fatty acids (PUFAs) docosahexaenoate (DHA) and its precursor eicosapentaenoate (EPA), and may contribute to the homeostasis of these retinal PUFAs. Omega hydroxylates saturated fatty acids such as laurate, myristate and palmitate, the catalytic efficiency decreasing in the following order: myristate > laurate > palmitate (C14>C12>C16). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Target Involvement

Bietti crystalline corneoretinal dystrophy (BCD)
Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass membrane protein.
Target Protein Families

Cytochrome P450 family
Target Tissue Specificity

Broadly expressed. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, retina, retinal pigment epithelium (RPE) and lymphocytes.
Target Synonyms

CYP4V2; Cytochrome P450 4V2; Docosahexaenoic acid omega-hydroxylase CYP4V2; Long-chain fatty acid omega-monooxygenase
Target Background

This gene encodes a member of the cytochrome P450 hemethiolate protein superfamily which are involved in oxidizing various substrates in the metabolic pathway. It is implicated in the metabolism of fatty acid precursors into n-3 polyunsaturated fatty acids. Mutations in this gene result in Bietti crystalline corneoretinal dystrophy.

Rabbit anti-Human CYP4V2 Polyclonal Antibody

Specifications

Immunogen Information

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