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The antibody against gL was raised in rabbit using the Recombinant Human cytomegalovirus Envelope glycoprotein L protein (31-278AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
The antibody against gL was raised in rabbit using the Recombinant Human cytomegalovirus Envelope glycoprotein L protein (31-278AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
$299.00
| Cat.No | ADC-46064A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | gL |
| Target Synonyms | gL antibody; UL115Envelope glycoprotein L antibody; gL antibody | Form | Liquid |
| Species Reactivity | Human cytomegalovirus | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | FITC conjugated | Storage | Upon receipt |
| Immunogen Description | Recombinant Human cytomegalovirus Envelope glycoprotein L protein (31-278AA) | Target Species | Human cytomegalovirus |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | F5HCH8 |
Uniprot Id
F5HCH8
Target Species
Human cytomegalovirus
Target Name
GL
Target Function
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH. In human cytomegalovirus, forms two distincts complexes to mediate viral entry, a trimer and a pentamer at the surface of the virion envelope. The gH-gL-gO trimer is required for infection in fibroblasts by interacting with host PDGFRA. The gH-gL-UL128-UL130-UL131A pentamer is essential for viral entry in epithelial, endothelial and myeloid cells via interaction with host NRP2.
Target Subcellular Location
Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network.
Target Protein Families
Herpesviridae glycoprotein L family
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