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The antibody against D2HGDH was raised in rabbit using the Recombinant Human D-2-hydroxyglutarate dehydrogenase, mitochondrial protein (14-521AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against D2HGDH was raised in rabbit using the Recombinant Human D-2-hydroxyglutarate dehydrogenase, mitochondrial protein (14-521AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
$299.00
| Cat.No | ADC-25085A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | d2hgdh |
| Target Synonyms | D2HGDH antibody; D2HGDD-2-hydroxyglutarate dehydrogenase antibody; mitochondrial antibody; EC 1.1.99.- antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human D-2-hydroxyglutarate dehydrogenase, mitochondrial protein (14-521AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8N465 |
Uniprot Id
Q8N465
Target Species
Human
Target Name
D2HGDH
Target Full Name
D-2-hydroxyglutarate dehydrogenase, mitochondrial
Target Function
Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.
Target Involvement
D-2-hydroxyglutaric aciduria 1 (D2HGA1)
Target Subcellular Location
Mitochondrion.
Target Protein Families
FAD-binding oxidoreductase/transferase type 4 family
Target Research Area
Metabolism
Target Synonyms
D2HGDH; D2HGDD-2-hydroxyglutarate dehydrogenase; mitochondrial; EC 1.1.99.-
Target Background
This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features.
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