Rabbit anti-Human DACH1 Polyclonal Antibody

The antibody against DACH1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 450-570 of human DACH1 (NP_542937.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-02807A

Number

Cat.No	ADA-02807A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	DACH1
Target Synonyms	DACH; DACH1	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	293F	Application	ELISA, WB

Cat.No

ADA-02807A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

DACH1

Target Synonyms

DACH; DACH1

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

293F

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 450-570 of human DACH1 (NP_542937.2).	Target Species	Human
Immunogen Sequence	EGRRPGSHPSSHRSSSVSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDLAGHDMGHESKRMHIEKDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPFLFPDGLSSIET	Uniprot ID	Q9UI36

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 450-570 of human DACH1 (NP_542937.2).

Target Species

Human

Immunogen Sequence

EGRRPGSHPSSHRSSSVSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDLAGHDMGHESKRMHIEKDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPFLFPDGLSSIET

Uniprot ID

Q9UI36

Background Information

Uniprot Id

Q9UI36
Target Species

Human
Target Name

DACH1
Target Full Name

Dachshund homolog 1
Target Function

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.
Target Subcellular Location

Nucleus.
Target Protein Families

DACH/dachshund family
Target Tissue Specificity

Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen.
Target Synonyms

DACH; Dach1; DACH1_HUMAN; Dachshund family transcription factor 1; dachshund homolog 1 (Drosophila); Dachshund homolog 1; Dachsund homolog 1; FLJ10138; OTTHUMP00000018494
Target Background

This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene.

Rabbit anti-Human DACH1 Polyclonal Antibody

Specifications

Immunogen Information

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