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The antibody against DAO was raised in rabbit using the Recombinant Human D-amino-acid oxidase protein (1-347AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against DAO was raised in rabbit using the Recombinant Human D-amino-acid oxidase protein (1-347AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-40004A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DAO |
| Target Synonyms | D-amino-acid oxidase antibody; DAAO antibody; DAMOX antibody; DAO antibody; DAO1 antibody; EC 1.4.3.3 antibody; MGC35381 antibody; OXDA antibody; OXDA_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human D-amino-acid oxidase protein (1-347AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P14920 |
Uniprot Id
P14920
Target Species
Human
Target Name
DAO
Target Full Name
D-amino-acid oxidase
Target Function
Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
Target Involvement
Schizophrenia (SCZD)
Target Subcellular Location
Peroxisome.
Target Protein Families
DAMOX/DASOX family
Target Research Area
Metabolism
Target Synonyms
D-amino-acid oxidase; DAAO; DAMOX; DAO; DAO1; EC 1.4.3.3; MGC35381; OXDA; OXDA_HUMAN
Target Background
This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia.
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