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The antibody against DARS2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 406-645 of human DARS2 (NP_060592.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against DARS2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 406-645 of human DARS2 (NP_060592.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-01929A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DARS2 |
| Target Synonyms | LBSL; ASPRS; mtAspRS; MT-ASPRS; DARS2 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, BT-474, MCF7, Mouse liver, NCI-H460, U-251MG | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 406-645 of human DARS2 (NP_060592.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q6PI48 | Immunogen Sequence |
Uniprot Id
Q6PI48
Target Species
Human
Target Name
DARS2
Target Full Name
Aspartate--tRNA ligase, mitochondrial
Target Involvement
Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL)
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
Class-II aminoacyl-tRNA synthetase family, Type 1 subfamily
Target Synonyms
DARS2; Aspartate--tRNA ligase; mitochondrial; EC 6.1.1.12; Aspartyl-tRNA synthetase; AspRS
Target Background
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL).
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