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The antibody against DBH was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 388-617 of human DBH (NP_000778.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against DBH was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 388-617 of human DBH (NP_000778.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
Immunohistochemistry analysis of paraffin-embedded human liver using DBH antibody at dilution of 1:200 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
| Cat.No | ADA-05907A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DBH |
| Target Synonyms | DBM; ORTHYP1; DBH | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 388-617 of human DBH (NP_000778.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P09172 | Immunogen Sequence |
Uniprot Id
P09172
Target Species
Human
Target Name
DBH
Target Full Name
Dopamine beta-hydroxylase
Target Function
Conversion of dopamine to noradrenaline.
Target Involvement
Dopamine beta-hydroxylase deficiency (DBH deficiency)
Target Subcellular Location
[Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. Secreted.; Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass type II membrane protein.
Target Protein Families
Copper type II ascorbate-dependent monooxygenase family
Target Research Area
Neuroscience
Target Synonyms
dbh; DBM; Dopamine beta hydroxylase; Dopamine beta monooxygenase; Dopamine beta-hydroxylase (dopamine beta-monooxygenase); Dopamine beta-monooxygenase; DOPO_HUMAN; OTTHUMP00000022501; Soluble dopamine beta-hydroxylase
Target Background
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders.
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