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The antibody against DCLRE1A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DCLRE1A (NP_001258745.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against DCLRE1A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DCLRE1A (NP_001258745.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05726A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DCLRE1A |
| Target Synonyms | PSO2; SNM1; SNM1A; DCLRE1A | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, 293T, A-549, LO2, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DCLRE1A (NP_001258745.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q6PJP8 | Immunogen Sequence |
Uniprot Id
Q6PJP8
Target Species
Human
Target Name
DCLRE1A
Target Full Name
DNA cross-link repair 1A protein
Target Function
May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin. Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem).
Target Subcellular Location
Nucleus. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11, RAD50 and NBN) and BRCA1.
Target Protein Families
DNA repair metallo-beta-lactamase (DRMBL) family
Target Tissue Specificity
Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
Dclre1a; DCR1A_HUMAN; DNA cross link repair 1A; DNA cross link repair gene SNM1; DNA cross-link repair 1A protein; hSNM1; hSNM1A; PSO2; SNM1 homolog A
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