Rabbit anti-Human DCP1A Monoclonal Antibody

The antibody against DCP1A was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 483-582 of human DCP1A (Q9NPI6) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.

ADA-16112A

Number

Cat.No	ADA-16112A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	DCP1A
Target Synonyms	SMIF; SMAD4IP1; HSA275986; Nbla00360; DCP1A	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, 293T, HepG2, SH-SY5Y	Application	ELISA, WB, IF/ICC, IHC-P

Cat.No

ADA-16112A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

DCP1A

Target Synonyms

SMIF; SMAD4IP1; HSA275986; Nbla00360; DCP1A

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, 293T, HepG2, SH-SY5Y

Application

ELISA, WB, IF/ICC, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 483-582 of human DCP1A (Q9NPI6).	Target Species	Human
Immunogen Sequence	PVAGAPLVTATTTAVSSVLLAPSVFQQTVTRSSDLERKASSPSPLTIGTPESQRKPSIILSKSQLQDTLIHLIKNDSSFLSTLHEVYLQVLTKNKDNHNL	Uniprot ID	Q9NPI6

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 483-582 of human DCP1A (Q9NPI6).

Target Species

Human

Immunogen Sequence

PVAGAPLVTATTTAVSSVLLAPSVFQQTVTRSSDLERKASSPSPLTIGTPESQRKPSIILSKSQLQDTLIHLIKNDSSFLSTLHEVYLQVLTKNKDNHNL

Uniprot ID

Q9NPI6

Background Information

Uniprot Id

Q9NPI6
Target Species

Human
Target Name

DCP1A
Target Full Name

mRNA-decapping enzyme 1A
Target Function

Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. Essential for embryonic development.
Target Subcellular Location

Cytoplasm, P-body. Nucleus.
Target Protein Families

DCP1 family
Target Tissue Specificity

Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

DCP1 decapping enzyme homolog A; Dcp1a; DCP1A_HUMAN; Decapping enzyme hDcp1a; Decapping mRNA 1A; HSA275986; mRNA decapping enzyme 1A; mRNA-decapping enzyme 1A; Nbla00360; Putative protein product of Nbla00360; Smad4 interacting transcriptional co activator ; Smad4-interacting transcriptional co-activator ; Smad4-interacting transcriptional co-activator; SMAD4IP1; SMIF; Transcription factor SMIF
Target Background

Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants.

Rabbit anti-Human DCP1A Monoclonal Antibody

Specifications

Immunogen Information

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