Rabbit anti-Human Desmoglein 2 Monoclonal Antibody

The antibody against Desmoglein 2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1001-1118 of human Desmoglein 2 (Q14126) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-13237A

Number

Cat.No	ADA-13237A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	Desmoglein 2
Target Synonyms	HDGC; CDHF5; Desmoglein 2	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, HepG2	Application	ELISA, WB

Cat.No

ADA-13237A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

Desmoglein 2

Target Synonyms

HDGC; CDHF5; Desmoglein 2

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, HepG2

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1001-1118 of human Desmoglein 2 (Q14126).	Target Species	Human
Immunogen Sequence	PLEGTQHLQDVPYVMVRERESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTENSMTARNTTVSGAGVPGPLPDFGLEESGHSNSTITTSSTRVTKHSTVQHSYS	Uniprot ID	Q14126

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1001-1118 of human Desmoglein 2 (Q14126).

Target Species

Human

Immunogen Sequence

PLEGTQHLQDVPYVMVRERESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTENSMTARNTTVSGAGVPGPLPDFGLEESGHSNSTITTSSTRVTKHSTVQHSYS

Uniprot ID

Q14126

Background Information

Uniprot Id

Q14126
Target Species

Human
Target Name

DSG2
Target Full Name

Desmoglein-2
Target Function

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Target Involvement

Arrhythmogenic right ventricular dysplasia, familial, 10 (ARVD10); Cardiomyopathy, dilated 1BB (CMD1BB)
Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Target Tissue Specificity

All of the tissues tested and carcinomas.
Target Research Area

Others
Target Synonyms

ARVC 10; ARVC10; ARVD 10; ARVD10; Cadherin family member 5; CDHF 5; CDHF5; CMD1BB; Desmoglein 2; Desmoglein-2; Desmoglein2; DSG 2; DSG2; DSG2_HUMAN; HDGC; HDGC included; Human Desmoglein colon; MGC117034; MGC117036; MGC117037
Target Background

This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10.

Rabbit anti-Human Desmoglein 2 Monoclonal Antibody

Specifications

Immunogen Information

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