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The antibody against DFFA was raised in rabbit using the Synthesized peptide derived from the Internal region of Human ICAD. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, IF, ELISA.
The antibody against DFFA was raised in rabbit using the Synthesized peptide derived from the Internal region of Human ICAD. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, IF, ELISA.
$167.00
Western Blot analysis of 3T3 cells using ICAD Polyclonal Antibody
Western Blot analysis of MCF7 NIH-3T3 SKOV3 cells using ICAD Polyclonal Antibody2
| Cat.No | ADC-38436A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DFFA |
| Target Synonyms | 45 kD, 45kDa, alpha polypeptide (DFFA), alpha polypeptide antibody; DNA fragmentation factor, alpha subunit antibody; DNA fragmentation factor, transcript variant 1 antibody; DNA fragmentation factor | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human ICAD. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O00273 |
Uniprot Id
O00273
Target Species
Human
Target Name
DFFA
Target Full Name
DNA fragmentation factor subunit alpha
Target Function
Inhibitor of the caspase-activated DNase (DFF40).
Target Subcellular Location
Cytoplasm.
Target Research Area
Cell Biology
Target Synonyms
A330085O09Rik; Caspase activated deoxyribonuclease inhibitor short form; DFF 1; DFF 45; DFF alpha; DFF-45; DFF1; DFF35; DFF45; DFFA; Dffa DNA fragmentation factor, alpha subunit ; DFFA_HUMAN; DNA fragmentation factor 45 kDa subunit; DNA Fragmentation Factor Alpha Subunit; DNA fragmentation factor subunit alpha; DNA fragmentation factor, 45 kD, alpha subunit ; DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1; DNA fragmentation factor, 45kDa, alpha polypeptide; DNA fragmentation factor, alpha subunit; DNAation factor 45 kDa subunit; H13; ICAD; ICAD L; ICAD S; Inhibitor of CAD; Inhibitor of Caspase Activated DNase; MGC143066; OTTHUMP00000001903 ; OTTHUMP00000001904 ; RP23 121D17.3
Target Background
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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