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The antibody against DGKI was raised in rabbit using the Synthesized peptide derived from C-terminal of Human DGKI. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IF.
The antibody against DGKI was raised in rabbit using the Synthesized peptide derived from C-terminal of Human DGKI. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IF.
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Western blot analysis of extracts from 293 cells, using DGKI antibody.
Immunofluorescence analysis of HeLa cells, using DGKI antibody.2
| Cat.No | ADC-42200A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DGKI |
| Target Synonyms | DGKIDiacylglycerol kinase iota antibody; DAG kinase iota antibody; EC 2.7.1.107 antibody; Diglyceride kinase iota antibody; DGK-iota antibody | Form | Liquid |
| Species Reactivity | Human, Rat | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, IF, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from C-terminal of Human DGKI. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O75912 |
Uniprot Id
O75912
Target Species
Human
Target Name
DGKI
Target Full Name
Diacylglycerol kinase iota
Target Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position. By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression.
Target Subcellular Location
Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse. Cell junction, synapse, postsynaptic density. Cell junction, synapse, synaptic cell membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Nucleus.
Target Protein Families
Eukaryotic diacylglycerol kinase family
Target Tissue Specificity
Specifically expressed in brain and retina. In brain, highly expressed in hippocampus, caudate nucleus, occipital pole, cerebral cortex, and cerebellum. Also detected in kidney.
Target Synonyms
DGKIDiacylglycerol kinase iota; DAG kinase iota; EC 2.7.1.107; Diglyceride kinase iota; DGK-iota
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