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The antibody against DHFR was raised in rabbit using the Recombinant Human Dihydrofolate reductase protein (2-187AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against DHFR was raised in rabbit using the Recombinant Human Dihydrofolate reductase protein (2-187AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human lung cancer using DHFR Antibody at dilution of 1:100
Immunofluorescent analysis of Hela cells using DHFR Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-40432A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DHFR |
| Target Synonyms | DHFR antibody; DHFRP1 antibody; Dihydrofolate reductase antibody; DYR antibody; DYR_HUMAN antibody; EC 1.5.1.3 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Dihydrofolate reductase protein (2-187AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P00374 |
Uniprot Id
P00374
Target Species
Human
Target Name
DHFR
Target Full Name
Dihydrofolate reductase
Target Function
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2.
Target Involvement
Megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD)
Target Subcellular Location
Mitochondrion. Cytoplasm.
Target Protein Families
Dihydrofolate reductase family
Target Tissue Specificity
Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood. Expression is higher in the adult brain than in the fetal brain.
Target Research Area
Cell Biology, Signal Transduction
Target Synonyms
DHFR; DHFRP1; Dihydrofolate reductase; DYR; DYR_HUMAN; EC 1.5.1.3
Target Background
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene.
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