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The antibody against DHRS9 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 18-319 of human DHRS9 (NP_001135743.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against DHRS9 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 18-319 of human DHRS9 (NP_001135743.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-09504A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DHRS9 |
| Target Synonyms | RDHL; RDH15; RDHTBE; SDR9C4; RDH-TBE; RETSDR8; hRoDH-E2; 3ALPHA-HSD; 3-alpha-HSD; DHRS9 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HT-29, Mouse pancreas, Mouse trachea, Rat trachea, THP-1 | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 18-319 of human DHRS9 (NP_001135743.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9BPW9 | Immunogen Sequence |
Uniprot Id
Q9BPW9
Target Species
Human
Target Name
DHRS9
Target Full Name
Dehydrogenase/reductase SDR family member 9
Target Function
3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. Plays also a role in the biosynthesis of retinoic acid from retinaldehyde. Can utilize both NADH and NADPH.
Target Subcellular Location
Microsome membrane. Endoplasmic reticulum membrane. Note=Associated with microsomal membranes.
Target Protein Families
Short-chain dehydrogenases/reductases (SDR) family
Target Tissue Specificity
Highly expressed in trachea and epidermis. Detected at lower levels in spinal cord, bone marrow, brain, tongue, esophagus, heart, colon, testis, placenta, lung, skeletal muscle and lymph node.
Target Synonyms
3 alpha hydroxysteroid dehydrogenase; 3-@alpha-HSD; 3-@alpha-hydroxysteroid dehydrogenase; 3-alpha hydroxysteroid dehydrogenase; 3-alpha-HSD; 3alpha HSD; Dehydrogenase/reductase SDR family member 9; DHRS9; DHRS9_HUMAN; NADP dependent retinol dehydrogenase/reductase; NADP-dependent retinol dehydrogenase/reductase; RDH-E2; Rdh15; RDHE2; RDHL; RDHTBE; retinol dehydrogenase homolog ; Retinol dehydrogenase; tracheobronchiol epithelail cell-specific; RETSDR8; SDR family; member 9; SDR9C4; short chain dehydrogenase/reductase family 9; short chain dehydrogenase/reductase family 9C; member 4 ; Short chain dehydrogenase/reductase retSDR8; Short-chain dehydrogenase/reductase retSDR8
Target Background
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants.
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