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The antibody against DHX29 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1020-1369 of human DHX29 (NP_061903.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against DHX29 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1020-1369 of human DHX29 (NP_061903.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-07038A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DHX29 |
| Target Synonyms | DDX29; DHX29 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HepG2 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1020-1369 of human DHX29 (NP_061903.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q7Z478 | Immunogen Sequence |
Uniprot Id
Q7Z478
Target Species
Human
Target Name
DHX29
Target Full Name
ATP-dependent RNA helicase DHX29
Target Function
ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
Target Subcellular Location
Cytoplasm.
Target Protein Families
DEAD box helicase family, DEAH subfamily
Target Synonyms
DHX29; DDX29ATP-dependent RNA helicase DHX29; EC 3.6.4.13; DEAH box protein 29; Nucleic acid helicase DDXx
Target Background
This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells.
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