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The antibody against DHX33 was raised in rabbit using the Recombinant Human ATP-dependent RNA helicase DHX33 protein (116-357AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against DHX33 was raised in rabbit using the Recombinant Human ATP-dependent RNA helicase DHX33 protein (116-357AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human breast cancer using DHX33 Antibody at dilution of 1:1002
| Cat.No | ADC-14923A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DHX33 |
| Target Synonyms | DHX33 antibody; DDX33ATP-dependent RNA helicase DHX33 antibody; EC 3.6.4.13 antibody; DEAH box protein 33 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human ATP-dependent RNA helicase DHX33 protein (116-357AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9H6R0 |
Uniprot Id
Q9H6R0
Target Species
Human
Target Name
DHX33
Target Full Name
ATP-dependent RNA helicase DHX33
Target Function
Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing. Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation. Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells. Required for NLRP3 activation induced by viral dsRNA and bacterial RNA. In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways.
Target Subcellular Location
Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm. Nucleus. Inflammasome.
Target Protein Families
DEAD box helicase family, DEAH subfamily
Target Research Area
Cell Biology
Target Synonyms
DHX33; DDX33ATP-dependent RNA helicase DHX33; EC 3.6.4.13; DEAH box protein 33
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