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The antibody against DIRAS3 was raised in rabbit using the Recombinant Human GTP-binding protein Di-Ras3 protein (1-229AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against DIRAS3 was raised in rabbit using the Recombinant Human GTP-binding protein Di-Ras3 protein (1-229AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human breast cancer using DIRAS3 Antibody at dilution of 1:100
| Cat.No | ADC-44420A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DIRAS3 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human GTP-binding protein Di-Ras3 protein (1-229AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O95661 |
Uniprot Id
O95661
Target Species
Human
Target Name
DIRAS3
Target Full Name
GTP-binding protein Di-Ras3
Target Subcellular Location
Cell membrane; Lipid-anchor; Cytoplasmic side.
Target Protein Families
Small GTPase superfamily, Di-Ras family
Target Tissue Specificity
Expressed in normal ovarian and breast epithelial cells but not in ovarian and breast cancers.
Target Research Area
others
Target Synonyms
DIRA3; DIRA3_HUMAN; DIRAS family GTP binding RAS like 3; DIRAS family GTPase 3; DIRAS family; GTP-binding RAS-like protein 3; DIRAS3; Distinct subgroup of the Ras family member 3; GTP binding protein Di Ras3; GTP-binding protein Di-Ras3; NOEY2; Ras homolog gene family member I; Rho related GTP binding protein RhoI; Rho-related GTP-binding protein RhoI; RHOI
Target Background
This gene encodes a member of the ras superfamily. This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression. The encoded protein acts as a tumor suppressor whose function is abrogated in many ovarian and breast cancers. This protein may also play a role autophagy in certain cancer cells by regulating the autophagosome initiation complex.
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