Rabbit anti-Human DIS3 Polyclonal Antibody

Uniprot Id

Q9Y2L1

Target Species

Human

Target Name

DIS3

Target Full Name

Exosome complex exonuclease RRP44

Target Function

Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.

Target Subcellular Location

Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus.

Target Protein Families

RNR ribonuclease family

Target Tissue Specificity

Widely expressed.

Target Synonyms

2810028N01Rik; bA555G22; Dis3; DIS3 homolog; exosome endoribonuclease and 3'-5' exoribonuclease; DIS3 mitotic control homolog (S. cerevisiae); DIS3 mitotic control homolog; DIS3 mitotic control; S. cerevisiae; homolog of; dis3p; EXOSC11; Exosome complex exonuclease RRP44; exosome component 11; KIAA1008; Mitotic control protein dis3 homolog ; Protein DIS3 homolog; Ribosomal RNA processing protein 44 ; Ribosomal RNA processing protein 44; S. cerevisiae; homolog of; Ribosomal RNA-processing protein 44; RP11-342J4.3; RRP44 ; RRP44_HUMAN

Target Background

Enables 3'-5'-exoribonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process and rRNA catabolic process. Located in cytosol and nucleoplasm. Part of nuclear exosome (RNase complex).